Pipeline

pipeline

Multiple sclerosis is an inflammatory and demyelinating disorder of the central nervous system affecting 2.3 million people worldwide. Myelin is a sheath around nerves that aids in conducting nerve impulses. Demyelination is a breakdown of this sheath. It is not reversible naturally or through existing drugs. As MS progresses, it causes pain affecting muscles, nerves, and joints, spasms, stiffness, and tremors, body mobility limitations and weakness, difficulty chewing or swallowing, in addition to speech difficulties. Currently, there are several approved drugs on the market, all of which, are primarily for the relief of symptoms and none are disease-modifying or curative. Our preclinical data suggest that EHP-101 has the potential to be neuroprotective and disease-modifying, which could potentially be a significant advantage in the market.

Phase 1 human study successfully completed. The initiation of the first Phase II study expected
before the end of 2019.

Scleroderma is an autoimmune disease that causes fibrosis, or thickening and scarring, of skin and internal organs. It affects over 180,000 patients in the USA. There is currently no cure and it is classified as an orphan disease in the US and EU. It is classified as an orphan disease (under 200,000 patients in a jurisdiction) in the US and EU. Currently, there is no cure for scleroderma and approved therapies on the market today only address symptoms and are highly toxic. Our preclinical data in scleroderma suggests that EHP-101 may positively affect multiple anti-fibrotic pathways. Additionally, EHP-101 has been granted Orphan Drug Designation by the FDA in the United States and the EMA in Europe.

Phase 1 human study successfully completed. The initiation of the first Phase II study expected
before the end of 2019.
Granted US FDA and EU EMA Orphan Drug Designation

Parkinson’s disease is an incurable neurodegenerative disorder affecting nearly 10 million people worldwide. Primarily it is a disease where the nerve cells stop producing a substance called dopamine, which helps transmit impulses from the brain to the muscles. It results in tremors, slowness and stiffness, impaired balance, and rigidity of the muscles. These symptoms get worse over time.Currently, there is no cure for Parkinson’s disease, however, preclinical data show the potential of our drug, EHP-102, to provide neuroprotection and antiinflammation to improve clinical outcomes. Additionally, our treatment has shown the potential to reduce the loss of production of dopamine, the main issue with Parkinson’s disease.

Huntington’s disease is an inherited disease that causes the progressive breakdown of nerve cells. It deteriorates patients’ physical and mental abilities to the extent that they are unable to care for themselves. It has no cure. In the U.S., approximately 30,000 people are symptomatic and more than 200,000 are at risk of inheriting the disease. Currently, there are no drugs to slow or stop the progression of Huntington disease. There are specific drugs available to reduce some of the symptoms. Our preclinical data suggest that the neuroprotective potential of EHP-102 may provide a significant opportunity in the market. Additionally, EHP-102 has been granted Orphan Drug Designation by the FDA in the United States and intend to apply for Orphan Drug Designation to the EMA in Europe.

Preclinical proof-of-concept has been established for HD. Chemistry, formulation & manufacturing development is in progress. Clinical-enabling studies expected to start once manufacturing and formulation development completed (expected in 2019).
Granted US Orphan Drug Designation.

PIPELINE