We are passionate about what matters most — patients.

Millions of people are suffering worldwide from life-threatening conditions with significant unmet medical needs and no cures. We are a team of experienced doctors, award-winning scientists and biotech innovators who joined forces in 2017 to answer the urgent call for new treatments. We are all impacted by these diseases directly or indirectly as patients, loved ones, caregivers and healthcare professionals.

“With patients at the core of our mission, we are dedicated to promoting health and improving quality of life through cannabinoid science for people suffering from diseases with unmet medical need around the world. With our experienced team, our world-class advisors, our unique and powerful technology and the positive results we have accomplished in our studies to date, we continue to advance our mission by developing potentially new treatments for many diseases that today are incurable.”

Dr. Jim DeMesa, President & CEO

Pipeline

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Current Clinical Trials

We are currently initiating enrollment for our Phase IIa clinical trial of EHP-101 in systemic sclerosis patients (a severe form of scleroderma) in the United States, Australia, and New Zealand.

View our clinical trials

Commonly Asked Questions

At this time we are not recruiting patients. Once the study is open for recruitment, we will update the clinicaltrials.gov website. We have received approval to begin the Phase 2 clinical trial of EHP-101 for the treatment of systemic sclerosis, and we have begun enrolling patients and plan to have our first patient in in June 2020, so we are on track. (This is of course subject to any delays due to COVID-19.) Please note that our first research centers for this Phase 2 clinical trial will be located in Australia and the US.

You may find the eligibility criteria on the clinicaltrials.gov website by clicking here, however, you will need to speak directly with your doctor to determine eligibility. Additionally, you or your doctor may contact the study research staff using the contacts provided on the clinicaltrials.gov website to learn more information.

Our medicines initially target four diseases: multiple sclerosis, scleroderma, Parkinson’s disease and Huntington’s disease.

EHP-101 is a first-in-class, potentially disease-modifying therapy, initially targeting multiple sclerosis and scleroderma. It is a new drug that leverages the known benefi­ts of cannabis molecules called cannabinoids by modifying them to also target other validated disease-related pathways that may have beneficial impacts on those diseases. EHP-101 has been shown to be safe, anti-inflammatory, neuroprotective, pain relieving, preventative of growth and/or spreading, and to reduce clinical signs of disease progression in preclinical models. A Phase 2 clinical trial of EHP-101 in systemic sclerosis patients (a severe form of scleroderma) is currently underway in Australia and the US. For more information, please visit https://emeraldpharma.life/ehp-101/.

EHP-102 is an oral pharmaceutical product candidate derived from cannabigerol (CBG), another key cannabinoid molecule. CBG has been shown to be anti-inflammatory and shows evidence of neuroprotection. The novel active molecule of EHP-102 has been modified to provide even more potent effects compared to CBG by also affecting PPARγ, a key molecular target for the treatment of Huntington’s disease and Parkinson’s disease, as well as other pathways involved in the pathophysiology of neurodegenerative diseases. These characteristics have led EHP to develop this proprietary new drug candidate for Huntington’s disease and Parkinson’s disease. For more information, please visit https://emeraldpharma.life/ehp-102/. 

Clinical trials for new treatments are always tested through several steps called phases. The typical phases of clinical trials are:

Phase 1: Safety

Phase 1 focuses on the safety of a drug. It is usually conducted with healthy volunteers with the goal to determine the drug’s most frequent and serious adverse events, at what dose level and, often, how the drug is broken down and excreted by the body. These trials usually involve a small number of participants.

Phase 2: Safety & Efficacy

A Phase 2 clinical trial is used to gather preliminary data on whether a drug works in people who have a certain condition/disease (that is, the drug’s effectiveness). Participants receiving the drug may be compared to similar participants receiving an inactive substance (called a placebo) or a different drug. Safety continues to be evaluated and short-term adverse events are studied. Usually, fewer than 100 people participate Phase 2 trials.

Phase 3: Safety & Efficacy

Phase 3 gathers more information about a drug’s safety and effectiveness by studying different populations with what would be considered a drug, drug combination, and dosage that might be used in the clinic (i.e. commercially). The drug being studied is compared to a placebo or competitive drug and uses very high standards to ensure the quality of the results – commonly used elements of high-quality clinical study design include being randomized, double-blind, and placebo-controlled. Phase 3 trials may include people from all over the world. The usual number of people in the trial is several hundred to several thousand.

A Phase 3 study is typically undertaken only with expectation that the drug and study design has a good prospect of proving the drug’s clinical utility and being given regulatory and marketing approval by an agency such as the US Food and Drug Administration (FDA).

Phase 4: Additional Research

Phase 4 is sometimes initiated after the FDA has approved a drug for marketing. These trials gather additional information about a drug’s safety, efficacy, or optimal use.

Emerald Health Pharmaceuticals is a clinical development stage company. Our Phase 2 clinical trial of EHP-101 in systemic sclerosis patients (a severe form of scleroderma) is currently underway in Australia and the US.

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